Posts Tagged ‘Induction of Glial L-CCR mRNA Expression in Spinal Cord and Brain in Experimental Autoimmune Encephalomyelitis’
woensdag, december 7th, 2011
| Title | Induction of Glial L-CCR mRNA Expression in Spinal Cord and Brain in Experimental Autoimmune Encephalomyelitis |
| Screenshot |  |
| Year | 2004 |
| Estimated date | 2003-06-01 |
| Category | Scientific Publication |
| Platform | None |
| Description | ABSTRACT Chemokines and chemokine receptors are important regulators of leukocyte
trafficking and immune response. It is well established that chemokines and their
receptors are also expressed in the central nervous system (CNS), where their expression
has been associated with various neuroinflammatory diseases, such as multiple
sclerosis (MS). One of the most important chemokines involved in MS pathology is CCL2
(previously known as MCP-1). CCL2, released by glial cells, activates the chemokine
receptor CCR2, causing the infiltration of blood monocytes in tissues affected by MS.
There is evidence, however, that CCL2 also has local effects on CNS cells, including
induction or modulation of cytokine release and synthesis of matrix metalloproteinases,
that might contribute to CNS pathology. These effects are most likely independent of
CCR2, since CCR2 expression in glial cells is rarely observed. We have recently provided
evidence for the presence of an alternative CCL2 receptor in glial cells called L-CCR and
have investigated the expression of L-CCR mRNA in a murine EAE model. It is shown
that L-CCR mRNA is expressed in infiltrating macrophages during EAE, but not in
infiltrating T cells. Prominent expression of L-CCR mRNA was detected in astrocytes
and microglia already at early time points throughout the brain and spinal cord supporting
the hypothesis that L-CCR expression in glial cells is related to CNS inflammation. |
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Tags: 2004, Induction of Glial L-CCR mRNA Expression in Spinal Cord and Brain in Experimental Autoimmune Encephalomyelitis, None, Scientific Publication
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