Posts Tagged ‘2008’
woensdag, december 7th, 2011
| Title | Association Between Donor MBL Promoter Haplotype and Graft Survival and the Development of BOS After Lung Transplantation |
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| Year | 2008 |
| Estimated date | 2008-05-01 |
| Category | Scientific Publication |
| Platform | None |
| Description | Background. Lung transplantation is a well accepted therapy for end-stage lung disease, despite high mortality rates.
Mortality after transplantation is mainly caused by allograft failure in the first years after transplantation. Mannose
binding lectin (MBL), a recognition molecule of innate immunity, has been associated with transplant outcome in
other solid organ transplantation. In this study, the effect of donor- and recipient-MBL genotype on lung transplant
outcome was investigated.
Materials and Methods. All lung transplantations performed in our center, except from retransplantations and combined
lung–liver or heart–lung transplantations, were included. Genotyping of theMBL2variants (promoter: L/H, Y/X,
and P/Q allele and exon 1: A/D, A/B, and A/C allele) was performed in donor and recipient DNA. Analyses on graft
survival and the development of bronchiolitis obliterans syndrome were performed with Kaplan-Meier (log rank)
survival analysis.
Results. Of the 277 included cases, DNA was available from 189 donors and 200 recipients and genotyping of the
promoter single nucleotide polymorphisms was successful in 184 donors and 198 recipients and of the exon 1 single
nucleotide polymorphisms in 181 donors and 193 recipients. Patients who received a graft from a donor with an X-allele
had better graft survival (P0.007) and bronchiolitis obliterans syndrome free survival (P0.007). Recipient MBL
genotype was not associated with transplant outcome.
Conclusion. The donor X-allele, which corresponds to the LXPA haplotype is associated with superior lung transplant
outcome. Our findings might prove to be important in finding ways to optimize outcome after lung transplantation. (Transplantation 2008;86: 1857–1863) |
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Tags: 2008, Association Between Donor MBL Promoter Haplotype and Graft Survival and the Development of BOS After Lung Transplantation, None, Scientific Publication
Posted in Scientific publication | Reacties uitgeschakeld
woensdag, december 7th, 2011
| Title | Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity |
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| Year | 2008 |
| Estimated date | 2008-04-01 |
| Category | Scientific Publication |
| Platform | None |
| Description | ABSTRACT
Background: Several findings link systemic lupus
erythematosus (SLE) with C1q, the first molecule of the
classical complement pathway. Polymorphisms of the
C1qA gene are associated with low serum C1q levels in
patients with cutaneous LE, but C1q polymorphisms have
not been studied in patients with systemic lupus.
Objective: To determine whether polymorphisms of the
C1q genes are associated with SLE, disease phenotypes,
serum C1q and CH50 levels.
Methods: DNA for genetic analysis was obtained from
103 Caucasian patients with SLE and their family
members. Five tag single nucleotide polymorphisms (tag
SNPs) served as unique markers for underlying SNPs in
the genes of the C1q protein. The pedigree disequilibrium
test (PDT) was applied to trios to determine association of
markers with SLE, SLE phenotypes, low serum C1q and
low CH50. Single SNP association and haplotype analysis
was also performed.
Results: The PDT revealed a significant association of the
tag SNP rs631090 (covering the C1qB gene) with SLE
(p=0.02). Rs631090 was moderately associated with
low serum C1q levels (p=0.06). In addition, the tag
SNPs rs292001 and rs294183 were associated with more
severe SLE (Systemic Lupus Erythematosus International
Collaborating Clinics (SLICC) damage index score.0;
p=0.007 and p=0.02, respectively). Haplotype analysis
and single SNP association analysis showed no significant
associations, but additional analyses revealed that marker
rs587585 is associated with low serum C1q and CH50
levels.
Conclusions: C1q polymorphisms are associated with
SLE, serum C1q and CH50 levels in a stable founder
population of patients with SLE. Although the studied
population was small and allele frequencies were low, this
is the first study to suggest an association of C1q
polymorphisms with SLE.
Ann Rheum Dis 2009;68:715–720. doi:10.1136/ard.2007.085688 |
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Tags: 2008, Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity, None, Scientific Publication
Posted in Scientific publication | Reacties uitgeschakeld
dinsdag, december 6th, 2011
| Title | Ready for Freddie |
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| Year | 2008 |
| Estimated date | 2008-12-26 |
| Category | Music |
| Platform | Commodore 64 |
| Description | The tune is from 1992 and nice melodic, with bass loops. It's from a period I had sworn off use of filters to get back to the root of the sound. Released only in 2008 with a new player. |
| File | Download |
Tags: 2008, Commodore 64, Music, Ready for Freddie
Posted in Music | Reacties uitgeschakeld
dinsdag, december 6th, 2011
| Title | Yuntarc |
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| Year | 2008 |
| Estimated date | 2008-12-26 |
| Category | Music |
| Platform | Commodore 64 |
| Description | The tune is from 1992, but the whole file (player and stuff) from 2008. The tune was never released before that. I like the tune and have recorded it in 1997 or so with my friend Dries. It's a very mature tune, and created in the late c64 period. |
| File | Download |
Tags: 2008, Commodore 64, Music, Yuntarc
Posted in Music | Reacties uitgeschakeld
maandag, december 5th, 2011
| Title | Go Go Go! |
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| Year | 2008 |
| Estimated date | 2002-2-01 |
| Category | Music |
| Platform | Commodore 64 |
| Description | Go Go Go! was my last Cybertracker tune. I remember Reyn Ouwehand liked the progression of the song. The tune takes use of the player-routine to the max and stretches it here and there. This tune would not pack succesfully with Cyberbrain's packer, and indeed it does look to use up all raster time. It is a fast paced tune with lots of sync and ringmod. |
| File | Download |
Tags: 2008, Commodore 64, Go go go!, Music
Posted in Music | Reacties uitgeschakeld
maandag, december 5th, 2011
| Title | Extremely Cool |
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| Year | 2008 |
| Estimated date | 2008-11-16 |
| Category | Music |
| Platform | Commodore 64 |
| Description | This is my first tune done in Goattracker and a cover from my PC tune from 1996 (created in Fasttracker). It is still indeed Extremely Cool. Love the funk, solos and sounds. 8580. |
| File | Download |
Tags: 2008, Commodore 64, Extremely Cool, Music
Posted in Music | Reacties uitgeschakeld
maandag, december 5th, 2011
| Title | Digitune |
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| Year | 2008 |
| Estimated date | 2008-02-18 |
| Category | Software |
| Platform | Commodore 64 |
| Description | My code for a front-end player for Active's never released digitune (1992), until 2008. |
| File | Download |
Tags: 2008, Commodore 64, Digitune, Software
Posted in Software | Reacties uitgeschakeld
maandag, december 5th, 2011
| Title | N.H. Digi |
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| Year | 2008 |
| Estimated date | 2008-02-18 |
| Category | Software |
| Platform | Commodore 64 |
| Description | I coded the player front-end for Active's tune that was made for Xentax in 1992, but never really released. Until 2008. |
| File | Download |
Tags: 2008, Commodore 64, N.H. Digi, Software
Posted in Software | Reacties uitgeschakeld
