Posts Tagged ‘2008’

Association Between Donor MBL Promoter Haplotype and Graft Survival and the Development of BOS After Lung Transplantation

woensdag, december 7th, 2011
TitleAssociation Between Donor MBL Promoter Haplotype and Graft Survival and the Development of BOS After Lung Transplantation
Screenshotlogodoc
Year2008
Estimated date2008-05-01
CategoryScientific Publication
PlatformNone
DescriptionBackground. Lung transplantation is a well accepted therapy for end-stage lung disease, despite high mortality rates. Mortality after transplantation is mainly caused by allograft failure in the first years after transplantation. Mannose binding lectin (MBL), a recognition molecule of innate immunity, has been associated with transplant outcome in other solid organ transplantation. In this study, the effect of donor- and recipient-MBL genotype on lung transplant outcome was investigated. Materials and Methods. All lung transplantations performed in our center, except from retransplantations and combined lung–liver or heart–lung transplantations, were included. Genotyping of theMBL2variants (promoter: L/H, Y/X, and P/Q allele and exon 1: A/D, A/B, and A/C allele) was performed in donor and recipient DNA. Analyses on graft survival and the development of bronchiolitis obliterans syndrome were performed with Kaplan-Meier (log rank) survival analysis. Results. Of the 277 included cases, DNA was available from 189 donors and 200 recipients and genotyping of the promoter single nucleotide polymorphisms was successful in 184 donors and 198 recipients and of the exon 1 single nucleotide polymorphisms in 181 donors and 193 recipients. Patients who received a graft from a donor with an X-allele had better graft survival (P0.007) and bronchiolitis obliterans syndrome free survival (P0.007). Recipient MBL genotype was not associated with transplant outcome. Conclusion. The donor X-allele, which corresponds to the LXPA haplotype is associated with superior lung transplant outcome. Our findings might prove to be important in finding ways to optimize outcome after lung transplantation. (Transplantation 2008;86: 1857–1863)
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Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity

woensdag, december 7th, 2011
TitleAnalysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity
Screenshotlogodoc
Year2008
Estimated date2008-04-01
CategoryScientific Publication
PlatformNone
DescriptionABSTRACT Background: Several findings link systemic lupus erythematosus (SLE) with C1q, the first molecule of the classical complement pathway. Polymorphisms of the C1qA gene are associated with low serum C1q levels in patients with cutaneous LE, but C1q polymorphisms have not been studied in patients with systemic lupus. Objective: To determine whether polymorphisms of the C1q genes are associated with SLE, disease phenotypes, serum C1q and CH50 levels. Methods: DNA for genetic analysis was obtained from 103 Caucasian patients with SLE and their family members. Five tag single nucleotide polymorphisms (tag SNPs) served as unique markers for underlying SNPs in the genes of the C1q protein. The pedigree disequilibrium test (PDT) was applied to trios to determine association of markers with SLE, SLE phenotypes, low serum C1q and low CH50. Single SNP association and haplotype analysis was also performed. Results: The PDT revealed a significant association of the tag SNP rs631090 (covering the C1qB gene) with SLE (p=0.02). Rs631090 was moderately associated with low serum C1q levels (p=0.06). In addition, the tag SNPs rs292001 and rs294183 were associated with more severe SLE (Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) damage index score.0; p=0.007 and p=0.02, respectively). Haplotype analysis and single SNP association analysis showed no significant associations, but additional analyses revealed that marker rs587585 is associated with low serum C1q and CH50 levels. Conclusions: C1q polymorphisms are associated with SLE, serum C1q and CH50 levels in a stable founder population of patients with SLE. Although the studied population was small and allele frequencies were low, this is the first study to suggest an association of C1q polymorphisms with SLE. Ann Rheum Dis 2009;68:715–720. doi:10.1136/ard.2007.085688
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Ready for Freddie

dinsdag, december 6th, 2011
TitleReady for Freddie
Screenshotready
Year2008
Estimated date2008-12-26
CategoryMusic
PlatformCommodore 64
DescriptionThe tune is from 1992 and nice melodic, with bass loops. It's from a period I had sworn off use of filters to get back to the root of the sound. Released only in 2008 with a new player.
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Yuntarc

dinsdag, december 6th, 2011
TitleYuntarc
Screenshot74145
Year2008
Estimated date2008-12-26
CategoryMusic
PlatformCommodore 64
DescriptionThe tune is from 1992, but the whole file (player and stuff) from 2008. The tune was never released before that. I like the tune and have recorded it in 1997 or so with my friend Dries. It's a very mature tune, and created in the late c64 period.
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Go Go Go!

maandag, december 5th, 2011
TitleGo Go Go!
Screenshotlogosid
Year2008
Estimated date2002-2-01
CategoryMusic
PlatformCommodore 64
DescriptionGo Go Go! was my last Cybertracker tune. I remember Reyn Ouwehand liked the progression of the song. The tune takes use of the player-routine to the max and stretches it here and there. This tune would not pack succesfully with Cyberbrain's packer, and indeed it does look to use up all raster time. It is a fast paced tune with lots of sync and ringmod.
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Extremely Cool

maandag, december 5th, 2011
TitleExtremely Cool
Screenshotlogosid
Year2008
Estimated date2008-11-16
CategoryMusic
PlatformCommodore 64
DescriptionThis is my first tune done in Goattracker and a cover from my PC tune from 1996 (created in Fasttracker). It is still indeed Extremely Cool. Love the funk, solos and sounds. 8580.
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Digitune

maandag, december 5th, 2011
TitleDigitune
Screenshotdigitune
Year2008
Estimated date2008-02-18
CategorySoftware
PlatformCommodore 64
DescriptionMy code for a front-end player for Active's never released digitune (1992), until 2008.
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N.H. Digi

maandag, december 5th, 2011
TitleN.H. Digi
Screenshotnhdigi
Year2008
Estimated date2008-02-18
CategorySoftware
PlatformCommodore 64
DescriptionI coded the player front-end for Active's tune that was made for Xentax in 1992, but never really released. Until 2008.
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