Posts Tagged ‘2007’
woensdag, december 7th, 2011
| Title | Low Levels of sRAGE Are Associated With Increased Risk for Mortality in Renal Transplant Recipients |
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| Year | 2007 |
| Estimated date | 2007-05-01 |
| Category | Scientific Publication |
| Platform | None |
| Description | Objective. Infusion of the soluble form of the receptor for advanced glycation end-products (sRAGE) was protective
against atherosclerosis and nephropathy in animal models. In this study we investigated determinants of endogenous
sRAGE in renal transplant recipients and whether sRAGE was associated with mortality and graft loss.
Methods and Results. A total of 591 patients participated at a median time of 6 years after transplantation. Independent
determinants of sRAGE were mycophenolate mofetil medication (0.21, P0.001), creatinine clearance (0.15,
P0.001), BMI (0.12, P0.003) and fasting insulin concentration (0.14, P0.001). Low sRAGE levels were
associated with a 2–3 times higher risk for mortality especially after correction for creatinine clearance (P0.006).
Conclusion. A lack of sRAGE is a risk factor for mortality in renal transplant recipients. The putatively protective role
of sRAGE and in particular its association with mycophenolate mofetil usage needs further investigation. (Transplantation 2007;84: 659–663) |
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Tags: 2007, Low Levels of sRAGE Are Associated With Increased Risk for Mortality in Renal Transplant Recipients, None, Scientific Publication
Posted in Scientific publication | Reacties uitgeschakeld
woensdag, december 7th, 2011
| Title | Renal Function Dependent Association of AGTR1 Polymorphism (A1166C) and Electrocardiographic Left-Ventricular Hypertrophy |
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| Year | 2007 |
| Estimated date | 2007 |
| Category | Scientific Publication |
| Platform | None |
| Description | Background: The association of renin-angiotensin
system (RAS) polymorphisms and left-ventricular hypertrophy
(LVH) may depend on the presence of risk factors
for LVH, such as renal dysfunction. We studied whether
renal function modulates the association between RAS
polymorphisms and LVH in a cross-sectional study of
8592 inhabitants of Groningen.
Methods: Left-ventricular hypertrophy was determined
with electrocardiograms, using the Cornell voltage-duration
product. The following RAS polymorphisms were determined:
angiotensin II type-1 receptor (AGTR1 A1166C),
angiotensin-converting enzyme (ACE) insertion/deletion (I/
D), and angiotensinogen (AGT G-6A). The AGTR1 A1166C
and ACE I/D polymorphisms were in Hardy-Weinberg equilibrium.
Results: Electrocardiographic LVH was present in 417
(5.0%) subjects. Subjects with LVH were older (53 v 49
years) and overall had more cardiovascular risk factors.
Using logistic regression, creatinine clearance interacted
with the relationship between the AGTR1 A1166C polymorphism
and LVH (, 0.19; P .033). In subjects
with the CC genotype, in contrast to carriers of an A allele,
the prevalence of LVH increased with more pronounced
renal dysfunction. Creatinine clearance also interacted
with the relationship between the ACE I/D polymorphism
and LVH (, 0.12; P .037), although less strongly, and
the other way around. Creatinine clearance did not influence
the association between the AGT G-6A polymorphism
and LVH (, 0.006; P .491).
Conclusions: In this population-based study, the
AGTR1 A1166C polymorphism was associated with
LVH, dependent on concomitant renal dysfunction. A
weaker renal function dependent association between the
ACE I/D polymorphism and LVH was also observed.
Renal function should be taken into account as a relevant
environmental factor for the pathogenetic effects of RAS
polymorphisms. Am J Hypertens 2007;20:1097–1103
© 2007 American Journal of Hypertension, Ltd. |
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Tags: 2007, None, Renal Function Dependent Association of AGTR1 Polymorphism (A1166C) and Electrocardiographic Left-Ventricular Hypertrophy, Scientific Publication
Posted in Scientific publication | Reacties uitgeschakeld
