Posts Tagged ‘2005’
donderdag, december 15th, 2011
| Title | Werkbespreking juli 2005 |
| Screenshot |  |
| Year | 2005 |
| Estimated date | 2005-07-05 |
| Category | Scientific presentation |
| Platform | None |
| Description | I was invited to give a talk on my new research projects for my old colleagues at the Department of Medical Physiology of the UMCG in July 2005. I had moved on as post-doc after I finished my PhD project in 2003 at that department. |
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Tags: 2005, None, Scientific presentation, Werkbespreking juli 2005
Posted in Scientific presentation | Reacties uitgeschakeld
donderdag, december 15th, 2011
| Title | Werkbespreking oktober 2005 |
| Screenshot | |
| Year | 2005 |
| Estimated date | 2005-10-17 |
| Category | Scientific presentation |
| Platform | None |
| Description | I gave this presentation in October 2005 to my colleagues at the Department of Nephrology. No harm in publishing it now, since most things have been published. |
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Tags: 2005, None, Scientific presentation, Werkbespreking oktober 2005
Posted in Scientific presentation | Reacties uitgeschakeld
maandag, december 12th, 2011
| Title | SeXWAD |
| Screenshot |  |
| Year | 2005 |
| Estimated date | 2005-01-14 |
| Category | Software |
| Platform | PC |
| Description | A hastily programmed SXWAD extractor (Counterstrike). |
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Tags: 2005, PC, SeXWAD, Software
Posted in Software | Reacties uitgeschakeld
woensdag, december 7th, 2011
| Title | The role of the cytochrome P450 3A5 enzyme for blood pressure regulation in the general Caucasian population |
| Screenshot | |
| Year | 2005 |
| Estimated date | 2005-05-01 |
| Category | Scientific Publication |
| Platform | None |
| Description | Cytochrome P450 3A (CYP3A) enzymes are important for
drug metabolism in gut and liver. The CYP3A5 isoenzyme
is also expressed in the kidney and has been implicated in
renal sodium reabsorption and blood pressure regulation.
Its expression and activity is strongly linked to a polymorphism
(i.e. 6986G> A). Thus, appreciable expression is
found in carriers of the CYP3A5*1 (6986A) but not in
homozygous carriers of the CYP3A5*3 (6986G) allele. We
tested whether the presence of CYP3A5*1 affects blood
pressure in Caucasian individuals who were enrolled in the
Prevention of REnal and Vascular ENd stage Disease
(PREVEND) study. In addition, we evaluated whether the
genetic effect of CYP3A5*1 on blood pressure is modulated
by sodium intake. CYP3A5*1 was found in 13.3% (901
individuals) of the cohort (6777 individuals). Diastolic blood
pressure was not affected by CYP3A5*1. Overall, systolic
and pulse pressure were significantly lower in carriers of
CYP3A5*1, both after univariate analysis adjusted for age
(P = 0.012 and P = 0.008) and in logistic regression analysis
(P = 0.015 and P = 0.012). The effect on systolic blood
pressure was significantly modulated by sodium intake
(P = 0.038). In separate analysis according to gender,
CYP3A5*1 accounted for a significant age adjusted
decrease in systolic blood pressure ( – 1.6 mmHg, P= 0.04)
and pulse pressure ( – 1.2 mmHg, P = 0.04) in females but
not in men. The present study demonstrates that the
CYP3A5*1 allele affects systolic blood pressure and pulse
pressure in the general population. Its role in hypertensive
disease and potential gender differences should be
investigated in further studies. Pharmacogenetics and
Genomics 15:831–837 c 2005 |
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Tags: 2005, None, Scientific Publication, The role of the cytochrome P450 3A5 enzyme for blood pressure regulation in the general Caucasian population
Posted in Scientific publication | Reacties uitgeschakeld
