Posts Tagged ‘2005’

CCL2 -2518 PROMOTER POLYMORPHISM AND A HIGH VASCULAR RISK SCORE ARE ASSOCIATED WITH IMPAIRED RENAL FUNCTION IN THE GENERAL POPULATION

donderdag, december 22nd, 2011
TitleCCL2 -2518 PROMOTER POLYMORPHISM AND A HIGH VASCULAR RISK SCORE ARE ASSOCIATED WITH IMPAIRED RENAL FUNCTION IN THE GENERAL POPULATION
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Year2005
Estimated date2005-06-30
CategoryScientific Publication
PlatformNone
DescriptionAbstract for the American Society of Nephrology, 2005.
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Influence of renal function on association of CCR2-64I with mortality in the general population

donderdag, december 22nd, 2011
TitleInfluence of renal function on association of CCR2-64I with mortality in the general population
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Year2005
Estimated date2005-01-12
CategoryScientific Publication
PlatformNone
DescriptionAbstract for the Dutch Nefrologie Dagen, 2005
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Genetic epidemiology of complex traits: issues and methods

vrijdag, december 16th, 2011
TitleGenetic epidemiology of complex traits: issues and methods
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Year2005
Estimated date2005-11-27
CategoryScientific presentation
PlatformNone
DescriptionIn this presentation I outline my work and approach, as well as my own tool I created to analyse complex genetic traits, FGClustor.
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CCR2 V64I polymorphism: morbidity and mortality in PREVEND

vrijdag, december 16th, 2011
TitleCCR2 V64I polymorphism: morbidity and mortality in PREVEND
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Year2005
Estimated date2005-04-17
CategoryScientific presentation
PlatformNone
DescriptionMy presentation outlining the results of the CCR2V64I analysis in PREVEND.
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Werkbespreking juli 2005

donderdag, december 15th, 2011
TitleWerkbespreking juli 2005
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Year2005
Estimated date2005-07-05
CategoryScientific presentation
PlatformNone
DescriptionI was invited to give a talk on my new research projects for my old colleagues at the Department of Medical Physiology of the UMCG in July 2005. I had moved on as post-doc after I finished my PhD project in 2003 at that department.
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Werkbespreking oktober 2005

donderdag, december 15th, 2011
TitleWerkbespreking oktober 2005
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Year2005
Estimated date2005-10-17
CategoryScientific presentation
PlatformNone
DescriptionI gave this presentation in October 2005 to my colleagues at the Department of Nephrology. No harm in publishing it now, since most things have been published.
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SeXWAD

maandag, december 12th, 2011
TitleSeXWAD
Screenshotsexwad
Year2005
Estimated date2005-01-14
CategorySoftware
PlatformPC
DescriptionA hastily programmed SXWAD extractor (Counterstrike).
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The role of the cytochrome P450 3A5 enzyme for blood pressure regulation in the general Caucasian population

woensdag, december 7th, 2011
TitleThe role of the cytochrome P450 3A5 enzyme for blood pressure regulation in the general Caucasian population
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Year2005
Estimated date2005-05-01
CategoryScientific Publication
PlatformNone
DescriptionCytochrome P450 3A (CYP3A) enzymes are important for drug metabolism in gut and liver. The CYP3A5 isoenzyme is also expressed in the kidney and has been implicated in renal sodium reabsorption and blood pressure regulation. Its expression and activity is strongly linked to a polymorphism (i.e. 6986G> A). Thus, appreciable expression is found in carriers of the CYP3A5*1 (6986A) but not in homozygous carriers of the CYP3A5*3 (6986G) allele. We tested whether the presence of CYP3A5*1 affects blood pressure in Caucasian individuals who were enrolled in the Prevention of REnal and Vascular ENd stage Disease (PREVEND) study. In addition, we evaluated whether the genetic effect of CYP3A5*1 on blood pressure is modulated by sodium intake. CYP3A5*1 was found in 13.3% (901 individuals) of the cohort (6777 individuals). Diastolic blood pressure was not affected by CYP3A5*1. Overall, systolic and pulse pressure were significantly lower in carriers of CYP3A5*1, both after univariate analysis adjusted for age (P = 0.012 and P = 0.008) and in logistic regression analysis (P = 0.015 and P = 0.012). The effect on systolic blood pressure was significantly modulated by sodium intake (P = 0.038). In separate analysis according to gender, CYP3A5*1 accounted for a significant age adjusted decrease in systolic blood pressure ( – 1.6 mmHg, P= 0.04) and pulse pressure ( – 1.2 mmHg, P = 0.04) in females but not in men. The present study demonstrates that the CYP3A5*1 allele affects systolic blood pressure and pulse pressure in the general population. Its role in hypertensive disease and potential gender differences should be investigated in further studies. Pharmacogenetics and Genomics 15:831–837 c 2005
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