CCR5D32 genotype is associated with outcome in type 2 diabetes mellitus

TitleCCR5D32 genotype is associated with outcome in type 2 diabetes mellitus
Screenshotlogodoc
Year2009
Estimated date2009-05-01
CategoryScientific Publication
PlatformNone
Descriptiona b s t r a c t Aims: To test whether the genetic variant CCR5D32 in the CC-chemokine receptor 5, which is known to lead to CCR5 deficiency, is associated with mortality in type 2 diabetes patients. Methods: We examined the effect of presence or absence of the CCR5D32 on overall and cardiovascular mortality risk in the Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) cohort, a type 2 diabetes patient cohort. Results: We studied 756 patients with a mean duration of follow-up of 5.4 ( 1.4) years. 194 patients died during follow up of which 83 were cardiovascular deaths. 144 subjects (19%) carried the CCR5D32 deletion. CCR5D32 carriers had an adjusted hazard ratio of 0.62 (95%CI: 0.40–0.96; p = 0.03) for all-cause mortality and 0.63 (95%CI: 0.33–1.19; p = 0.16) for cardiovascular mortality. Conclusions: The presence of CCR5D32 is associated with better survival in type 2 diabetes patients. These data suggest that it is worthwhile to explore the protective potential of pharmacological blockade of CCR5 in type 2 diabetic patients Muntinghe FL, Gross S, Bakker SJ, Landman GW, van der Harst P, Bilo HJ, Navis G, Zuurman MW. CCR5Delta32 genotype is associated with outcome in type 2 diabetes mellitus. Diabetes Res Clin Pract. 2009 Nov;86(2):140-5. Epub 2009 Sep 9. PubMed PMID: 19744740.
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